DEPRESSED CD4/CD8 RATIO IN TPHA-NEGATIVE PATIENTS WITH SYPHILIS

被引：0
|
作者：
KANDA, T [1 ]
SHINOHARA, H [1 ]
SUZUKI, T [1 ]
MURATA, K [1 ]
机构：
[1] SHINOHARA HOSP,KIRYU,GUNMA 376,JAPAN
来源：
MICROBIOLOGY AND IMMUNOLOGY | 1992年 / 36卷 / 03期
关键词：
D O I：
10.1111/j.1348-0421.1992.tb01669.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Treponema pallidum hemagglutination assay (TPHA) is a widely used method for screening syphilis. We report our experience with six elderly (age 72.4 +/- 8.3 years) patients with syphilis, whose TPHA was negative. Their cardiolipin (RPR) and absorbed fluorescence treponemal tests (FTA-ABS) were positive. TPHA-negative patients with syphilis were compared with TPHA-positive syphilitics by immunological analysis. We found that both the numbers and the percentage of CD4 cells in TPHA-negative syphilitics were significantly lower than those in TPHA-positive syphilitics (722 +/- 142 vs. 1,064 +/- 141/mm3, P < 0.01: 35.1 +/- 6.9 vs. 48.4 +/- 6.4%, P < 0.01) and that the ratio of CD4 to CD8 was also lower in TPHA-negative syphilitics compared with TPHA-positive syphilitics (1.08 +/- 0.46 vs. 2.24 +/- 1.07, P < 0.05). These data suggest that the TPHA is insufficient for excluding elderly syphilitics because of immunological impairment seen in aged patients.
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页码：317 / 320
页数：4
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