DIFFERENTIAL-EFFECTS OF DOPAMINE-D2 AGONIST QUINPIROLE UPON THE DORSAL IMMOBILITY RESPONSE IN RATS

被引：6
作者：
MEYER, ME
MEYER, ME
POTTER, TJ
VANHARTESVELDT, C
机构：
[1] Department of Psychology, University of Florida, Gainesville
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 42卷 / 02期
关键词：
QUINPIROLE; DOPAMINE; D2-RECEPTOR; BIPHASIC EFFECT; DORSAL IMMOBILITY RESPONSE;
D O I：
10.1016/0091-3057(92)90524-J
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The effects of various dose levels of systemically injected quinpirole upon the dorsal immobility response (DIR) over a time course was investigated in male rats. A low dose of quinpirole (0.01 mg/kg) significantly attenuated the duration of the DIR following the 10-min interval, whereas the highest dose (1.0 mg/kg) had a biphasic effect so that at the 10-min interval the duration of the DIR was significantly potentiated and at the 60-min interval the duration of the DIR was significantly attenuated. The intermediate dose (0.1 mg/kg) had intermediate behavioral effects. The data support the growing evidence that quinpirole has differential effects upon behavior over time as a function of the dose levels. The present data were discussed in reference to presynaptic and postsynaptic dopamine D2 receptor theory.
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收藏
页码：257 / 259
页数：3
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