THE MURINE RAC1 GENE - CDNA CLONING, TISSUE DISTRIBUTION AND REGULATED EXPRESSION OF RAC1 MESSENGER-RNA BY DISASSEMBLY OF ACTIN MICROFILAMENTS

被引：0

作者：

MOLL, J ^{[1
]}

SANSIG, G ^{[1
]}

FATTORI, E ^{[1
]}

VANDERPUTTEN, H ^{[1
]}

机构：

[1] CIBA GEIGY AG,DEPT BIOTECHNOL,DIV PHARMA,K 681447,CH-4002 BASEL,SWITZERLAND

来源：

ONCOGENE | 1991年 / 6卷 / 05期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 886 bp cDNA encoding the murine rac1 protein has been isolated. The abundance of rac1 mRNA was determined in fourteen tissues from both mouse and pig. The mRNA 5' non-coding sequence is very rich in G + C, and has the potential to form several stable secondary structures. In addition, this region contains a putative open reading frame of 57 amino acids. Disruption of the actin microfilament network by cytochalasin B in LLC-PK1 cells results in down regulation of rac1 mRNA. In agreement with the proposed role of rac1 in exocytosis, these results could explain the inhibitory effect of cytochalasin B on secretory processes.

引用

页码：863 / 866

页数：4

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