THE MURINE RAC1 GENE - CDNA CLONING, TISSUE DISTRIBUTION AND REGULATED EXPRESSION OF RAC1 MESSENGER-RNA BY DISASSEMBLY OF ACTIN MICROFILAMENTS

被引：0
作者：
MOLL, J [1 ]
SANSIG, G [1 ]
FATTORI, E [1 ]
VANDERPUTTEN, H [1 ]
机构：
[1] CIBA GEIGY AG,DEPT BIOTECHNOL,DIV PHARMA,K 681447,CH-4002 BASEL,SWITZERLAND
来源：
ONCOGENE | 1991年 / 6卷 / 05期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A 886 bp cDNA encoding the murine rac1 protein has been isolated. The abundance of rac1 mRNA was determined in fourteen tissues from both mouse and pig. The mRNA 5' non-coding sequence is very rich in G + C, and has the potential to form several stable secondary structures. In addition, this region contains a putative open reading frame of 57 amino acids. Disruption of the actin microfilament network by cytochalasin B in LLC-PK1 cells results in down regulation of rac1 mRNA. In agreement with the proposed role of rac1 in exocytosis, these results could explain the inhibitory effect of cytochalasin B on secretory processes.
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页码：863 / 866
页数：4
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