PRIMARY STRUCTURES OF THE BOMBESIN-LIKE NEUROPEPTIDES IN FROG BRAIN SHOW THAT BOMBESIN IS NOT THE AMPHIBIAN GASTRIN-RELEASING PEPTIDE

被引：18
|
作者：
CONLON, JM [1 ]
OHARTE, F [1 ]
VAUDRY, H [1 ]
机构：
[1] UNIV ROUEN HAUTE NORMANDIE,MOLEC ENDOCRINOL LAB,CNRS,URA 650,INSERM,F-76134 MT ST AIGNAN,FRANCE
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 178卷 / 02期
关键词：
D O I：
10.1016/0006-291X(91)90139-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Peptides displaying gastrin-releasing peptide/bombesin-like immunoreactivity were isolated in pure form from an extract of the brain of the European green frog, Rana ridibunda. The primary structure of the more abundant peptide was established as: Gly-Ser-His-Trp-Ala-Val-Gly-His-Leu-Met.NH2. This sequence shows one substitution (Ser for Asn) compared with mammalian gastrin-releasing peptide (18-27) (neuromedin C). The extract also contained gastrin-releasing peptide but bombesin was absent. The data indicate that bombesin is not the amphibian counterpart of gastrin-releasing peptide. © 1991.
引用
收藏
页码：526 / 530
页数：5
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