NEUROMUSCULAR EFFECTS OF SUXAMETHONIUM IN MAN

被引：89
作者：
KATZ, RL
RYAN, JF
机构：
[1] Department of Anesthesiology, Columbia University, College of Physicians and Surgeons and the AnesthesiologyService, Presbyterian Hospital, New York City
来源：
BRITISH JOURNAL OF ANAESTHESIA | 1969年 / 41卷 / 05期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1093/bja/41.5.381
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Summary: The neuromuscular effects of suxamethonium (single dose and continuous infusion) were determined in anaesthetized patients. A marked variation in patient response was observed. The block was initially depolarizing but with increasing dosage and time became desensitizing. Tachyphylaxis was observed with repeated doses of suxamethonium but not with continuous infusion. The depth of anaesthesia was an important factor in determining the amount of suxamethonium required to produce satisfactory operating conditions. If suxamethonium was infused continuously for no more than 1 hour or infused intermittently for several hours, recovery was always rapid (3-21 minutes). However, in four of nine patients who received suxamethonium by continuous infusion for 2 hours recovery required 51-69 minutes. © 1969 John Sherratt and Son Ltd.
引用
收藏
页码：381 / +
页数：1
相关论文
共 33 条
[11]   HYDROLYSIS OF SUCCINYLCHOLINE SALTS [J].
FRASER, PJ .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1954, 9 (04) :429-436
[12]   CLINICAL USE OF A PHYSIOLOGICAL RESPIRATOR PRODUCING N2O AMNESIA-ANALGESIA [J].
FRUMIN, MJ .
ANESTHESIOLOGY, 1957, 18 (02) :290-299
[13]   NEUROMUSCULAR BLOCK IN MAN DURING PROLONGED ARTERIAL INFUSION WITH SUCCINYLCHOLINE [J].
GISSEN, AJ ;
KATZ, RL ;
KARIS, JH ;
PAPPER, EM .
ANESTHESIOLOGY, 1966, 27 (03) :242-&
[14]  
GREENE NM, 1968, CLINICAL ANESTHES ED, P153
[15]   RESPONSE IN DOGS TO RELAXANTS DERIVED FROM SUCCINIC ACID AND CHOLINE [J].
HALL, LW ;
LEHMANN, H ;
SILK, E .
BRITISH MEDICAL JOURNAL, 1953, 1 (4802) :134-136
[16]   STUDIES IN THE USE OF SUCCINYLCHOLINE .2. USE OF ANECTINE IN MAJOR THORACIC SURGERY [J].
HELMSWORTH, FW ;
SCHOTZ, S .
ANESTHESIOLOGY, 1956, 17 (01) :175-186
[17]   STUDIES IN THE USE OF SUCCINYLCHOLINE CHLORIDE (ANECTINE) .1. MUSCLE RELAXANT IN GENERAL ANESTHESIA [J].
HELMSWORTH, FW ;
SCHOTZ, S .
ANESTHESIOLOGY, 1955, 16 (06) :1009-1017
[18]  
KALOW W, 1957, J PHARMACOL EXP THER, V120, P203
[19]   COMPARISON OF ELECTRICAL AND MECHANICAL RECORDING OF SPONTANEOUS AND EVOKED MUSCLE ACTIVITY - CLINICAL VALUE OF CONTINUOUS RECORDING AS AN AID TO RATIONAL USE OF MUSCLE RELAXANTS DURING ANESTHESIA [J].
KATZ, RL .
ANESTHESIOLOGY, 1965, 26 (02) :204-&
[20]   NEUROMUSCULAR EFFECTS OF D-TUBOCURARINE EDROPHONIUM AND NEOSTIGMINE IN MAN [J].
KATZ, RL .
ANESTHESIOLOGY, 1967, 28 (02) :327-+
1234