A PRACTICAL TOTAL SYNTHESIS OF COCAINE ENANTIOMERS

被引：25
作者：
CASALE, JF
机构：
[1] State Bureau of Investigation, Raleigh, NC 27626-0500
来源：
FORENSIC SCIENCE INTERNATIONAL | 1987年 / 33卷 / 04期
关键词：
Cocaine; Enantiomers; Total synthesis;
D O I：
10.1016/0379-0738(87)90109-5
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
A simplifed total synthesis of the single enantiomers of cocaine and raceremic cocaine is outlined.The synthesis employs common laboratory glassware, reagents, and methods which can be performed in most forensic laboratories. The procedure for the isolation and purification of the dextrorotatory enantiomer of cocain is presented. © 1987.
引用
收藏
页码：275 / 298
页数：24
相关论文
共 48 条
[1]  
Adams R., 1941, ORG SYNTH, V1, P10
[2]  
ALLEN AC, 1981, J FORENSIC SCI, V26, P12
[3]  
BAZILEVSKAYA GI, 1958, IZV VYSSH UCHEBN ZAV, V2, P75
[4]   MASS SPECTROMETRY IN STRUCTURAL + STEREOCHEMICAL PROBLEMS .39. TROPANE ALKALOIDS [J].
BLOSSEY, EC ;
BUDZIKIEWICZ, H ;
FODOR, G ;
DJERASSI, C ;
OHASHI, M .
TETRAHEDRON, 1964, 20 (03) :585-&
[5]   SYNTHESES AND CONFORMATIONAL-ANALYSES OF ISOMERIC COCAINES - A PROTON AND C-13 NUCLEAR MAGNETIC-RESONANCE STUDY [J].
CARROLL, FI ;
COLEMAN, ML ;
LEWIN, AH .
JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (01) :13-19
[6]   COMPOUNDS AFFECTING CENTRAL NERVOUS-SYSTEM .4. 3BETA-PHENYLTROPANE-2-CARBOXYLIC ESTERS AND ANALOGS [J].
CLARKE, RL ;
DAUM, SJ ;
GAMBINO, AJ ;
ACETO, MD ;
PEARL, J ;
LEVITT, M ;
CUMISKEY, WR ;
BOGADO, EF .
JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (11) :1260-1267
[7]  
COOPER DA, 1984, J FORENSIC SCI, V29, P1045
[8]   PREPARATION OF GLUTARALDEHYDE AND PSEUDOPELLETIERINE [J].
COPE, AC ;
DRYDEN, HL ;
OVERBERGER, CG ;
DADDIECO, AA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1951, 73 (07) :3416-3418
[9]  
De Jong AWK, 1940, RECL TRAV CHIM PAY-B, V59, P27
[10]  
DEJONG A, 1942, REC TRAV CHIM PAYS B, V62, P54
12345