Omega-3 Fatty Acids: Possible Neuroprotective Mechanisms in the Model of Global Ischemia in Rats

被引：11

作者：

Pereira Nobre, Maria Elizabeth ^{[1
]}

Correia, Alyne Oliveira ^{[1
]}

Maciel Mendonca, Francisco Nilson ^{[1
]}

Araujo Uchoa, Luiz Ricardo ^{[1
]}

Nunes Vasconcelos, Jessica Tamara ^{[1
]}

Alencar de Araujo, Carlos Ney ^{[1
]}

de Castro Brito, Gerly Anne ^{[2
]}

Pinheiro Siqueira, Rafaelly Maria ^{[2
]}

Cerqueira, Gilberto dos Santos ^{[2
]}

Tavares Neves, Kelly Rose ^{[2
]}

Arida, Ricardo Mario ^{[3
]}

de Barros Viana, Glauce Socorro ^{[1
,2
]}

机构：

[1] Fac Med, Estacio Juazeiro do Norte FMJ, Rua Tenente Raimundo Rocha 515, BR-63040360 Juazeiro Do Norte, Ceara, Brazil

[2] Univ Fed Ceara, Rua Coronel Nunes de Melo 1127, BR-60430270 Fortaleza, Ceara, Brazil

[3] Fed Univ Sao Paulo UNIFESP, Rua Pedro de Toledo 669, BR-04039032 Sao Paulo, SP, Brazil

来源：

JOURNAL OF NUTRITION AND METABOLISM | 2016年 / 2016卷

关键词：

D O I：

10.1155/2016/6462120

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background. Omega-3 (omega 3) administration was shown to protect against hypoxic-ischemic injury. The objectives were to study the neuroprotective effects of omega 3, in a model of global ischemia. Methods. Male Wistar rats were subjected to carotid occlusion (30 min), followed by reperfusion. The groups were SO, untreated ischemic and ischemic treated rats with omega 3 (5 and 10 mg/kg, 7 days). The SO and untreated ischemic animals were orally treated with 1% cremophor and, 1 h after the last administration, they were behaviorally tested and euthanized for neurochemical (DA, DOPAC, and NE determinations), histological (Fluoro jade staining), and immunohistochemical (TNF-alpha, COX-2 and iNOS) evaluations. The data were analyzed by ANOVA and Newman-Keuls as the post hoc test. Results. Ischemia increased the locomotor activity and rearing behavior that were partly reversed by omega 3. Ischemia decreased striatal DA and DOPAC contents and increased NE contents, effects reversed by omega 3. This drug protected hippocampal neuron degeneration, as observed by Fluoro-Jade staining, and the increased immunostainings for TNF-alpha, COX-2, and iNOS were partly or totally blocked by omega 3. Conclusion. This study showed a neuroprotective effect of omega 3, in great part due to its anti-inflammatory properties, stimulating translational studies focusing on its use in clinic for stroke managing.

引用

页数：13

共 80 条

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