3 NEW POTENT CYTOTOXIC MACROLIDES CLOSELY-RELATED TO SPHINXOLIDE FROM THE NEW CALEDONIAN SPONGE NEOSIPHONIA-SUPERSTES

被引：45

作者：

DAURIA, MV

PALOMA, LG

MINALE, L

ZAMPELLA, A

VERBIST, JF

ROUSSAKIS, C

DEBITUS, C

机构：

[1] FAC PHARM NANTES,F-44035 NANTES,FRANCE

[2] ORSTOM,NOUMEA,NEW CALEDONIA

来源：

TETRAHEDRON | 1993年 / 49卷 / 38期

关键词：

MARINE MACROLIDES; CYTOTOXIC; SPONGE;

D O I：

10.1016/S0040-4020(01)96271-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new macrolides 2-4 have been isolated with sphinxolide 1 from the marine sponge N. superstes collected off New Caledonia. The structures of the new compounds were determined by interpretation of NMR spectral data as well as by comparison of spectral data with those of 1. These compounds were highly cytotoxic against various human carcinoma cells.

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页码：8657 / 8664

页数：8

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