PREVENTION OF NEGATIVE CHRONOTROPIC EFFECT OF ADENOSINE BY CAFFEINE

被引：5

作者：

CHIBA, S

HASHIMOTO, K

机构：

[1] Department of Pharmacology, Tohoku University School of Medicine, Sendai

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1969年 / 99卷 / 03期

关键词：

D O I：

10.1620/tjem.99.307

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A constant pressure perfusion of the sinus node artery was performed in ten vagotomized dogs. The selective administration of adenosine, AMP, ADP or ATP into this artery caused a negative chronotropic effect which was not blocked by either atropine or tetrodotoxin, but was blocked by the continuous infusion of caffeine or theophylline. In the meanwhile atrial fibrillation was readily induced by acetylcholine. © 1969, Tohoku University Medical Press. All rights reserved.

引用

页码：307 / 308

页数：2

共 6 条

[1]

DEGUBAREFF T, 1965, J PHARMACOL EXP THER, V148, P202

[2] The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. [J].