HYDROLYSIS OF PHOSPHATIDYLINOSITOL BY RARE-EARTH-METAL ION AS A PHOSPHOLIPASE-C MIMIC

被引：24

作者：

MATSUMURA, K ^{[1
]}

KOMIYAMA, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC ENGN,DEPT IND CHEM,TOKYO 113,JAPAN

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1994年 / 55卷 / 02期

关键词：

D O I：

10.1016/0162-0134(94)85037-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatidylinositol, a cell-membrane component responsible for the transduction of extracellular signals into cells, is hydrolyzed by rare earth metal chlorides (YCl3, LaCl3, EuCl3, CeCl3, and TmCl3) at pH 7.5-8.5 and 30 degrees C. YCl3 has the largest activity. A key step in the cell-to-cell communication has been successfully mimicked. In contrast, non-rare earth metal ions such as Fe(III), Zn(II), and Cu(II) show no measurable activity, confirming the overwhelming superiority of rare earth metal(III) ions.

引用

页码：153 / 156

页数：4

共 17 条

[1]

BAMANN E, 1954, BIOCHEM Z, V326, P89

[2]

BAMANN E, 1938, CHEM BER, V71, P1711

[3] EFFECTS OF METAL-IONS, INCLUDING MG2+ AND LANTHANIDES, ON THE CLEAVAGE OF RIBONUCLEOTIDES AND RNA MODEL COMPOUNDS [J].