ASSESSMENT OF RETINOL-BINDING PROTEIN EXCRETION IN NORMAL-CHILDREN

被引：40

作者：

SMITH, GC ^{[1
]}

WINTERBORN, MH ^{[1
]}

TAYLOR, CM ^{[1
]}

LAWSON, N ^{[1
]}

GUY, M ^{[1
]}

机构：

[1] E BIRMINGHAM DIST GEN HOSP,DEPT CLIN CHEM,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

来源：

PEDIATRIC NEPHROLOGY | 1994年 / 8卷 / 02期

关键词：

RETINOL-BINDING PROTEIN; ALBUMIN; EARLY-MORNING URINE; TUBULAR PROTEINURIA; RENAL DISEASE ASSESSMENT;

D O I：

10.1007/BF00865463

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Retinol-binding protein (RBP) is a low molecular weight protein freely filtered at the glomerulus. The fractional tubular reabsorption of RBP is 99.97% and increased excretion is therefore a sensitive marker of tubular dysfunction. We obtained early-morning urine specimens from 151 well children, from newborn to 16 years of age. RBP was measured using an enzyme-linked immunosorbent assay, albumin by a radioimmunoassay and creatinine by a modified Jaffe reaction. Protein excretion was assessed by calculating the protein:creatinine ratio for early-morning urine samples. We found a fall in both RBP and albumin excretion with increasing age, particularly in the 1st year of life, with a much wider variation in values from the infants studied. The mean excretion of RBP for children aged 0-6 months [51.4 (0.6-4,719) mug/mmol] was significantly higher (P <0.001) than the mean for children aged 6 months to 16-years [15.0 (3.8-60) mug/mmol]. It has been shown that measurement of tubular proteinuria using the RBP: creatinine ratio is useful in the assessment of children with renal disease and we propose a value two standard deviations above the geometric mean for the age of the patient as an upper limit of normal.

引用

页码：148 / 150

页数：3

共 22 条

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