MultiCenter Reliability of Diffusion Tensor Imaging

被引:65
作者
Magnotta, Vincent A. [1 ,2 ]
Matsui, Joy T. [2 ,3 ]
Liu, Dawei [4 ]
Johnson, Hans J. [2 ]
Long, Jeffrey D. [2 ]
Bolster, Bradley D., Jr. [5 ]
Mueller, Bryon A. [6 ]
Lim, Kelvin [6 ]
Mori, Susumu [7 ]
Helmer, Karl G. [8 ]
Turner, Jessica A. [9 ]
Reading, Sarah [10 ,11 ,12 ]
Lowe, Mark J. [13 ]
Aylward, Elizabeth [14 ]
Flashman, Laura A. [15 ]
Bonett, Greg [2 ,16 ]
Paulsen, Jane S. [2 ]
机构
[1] Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA
[2] Univ Iowa, Dept Psychiat, 500 Newton Rd,1-305 MEB, Iowa City, IA 52242 USA
[3] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA
[4] Univ Iowa, Dept Biostat, Iowa City, IA 52242 USA
[5] Siemens Med Solut USA Inc, MR R&D Collaborat, Rochester, MN USA
[6] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA
[7] Johns Hopkins Univ, Dept Radiol, Baltimore, MD USA
[8] Massachusetts Gen Hosp, Dept Radiol, Charlestown, MA USA
[9] MIND Res Network, Albuquerque, NM USA
[10] Johns Hopkins Univ, Dept Psychiat, Baltimore, MD USA
[11] James A Haley Vet Hosp, Mental Hlth & Behav Sci Serv, Tampa, FL 33612 USA
[12] Univ S Florida, Dept Psychiat & Neurosci, Tampa, FL USA
[13] Cleveland Clin Fdn, Dept Radiol, Cleveland, OH 44195 USA
[14] Seattle Childrens Hosp, Dept Radiol, Washington, DC USA
[15] Dartmouth Med Sch, Dept Psychiat, Hanover, NH USA
[16] Univ Calif Los Angeles, Los Angeles, CA USA
基金
美国国家卫生研究院;
关键词
diffusion tensor; fractional anisotropy; magnetic resonance; mean diffusivity; reliability; white matter;
D O I
10.1089/brain.2012.0112
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A number of studies are now collecting diffusion tensor imaging (DTI) data across sites. While the reliability of anatomical images has been established by a number of groups, the reliability of DTI data has not been studied as extensively. In this study, five healthy controls were recruited and imaged at eight imaging centers. Repeated measures were obtained across two imaging protocols allowing intra-subject and inter-site variability to be assessed. Regional measures within white matter were obtained for standard rotationally invariant measures: fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity. Intra-subject coefficient of variation (CV) was typically <1% for all scalars and regions. Inter-site CV increased to similar to 1%-3%. Inter-vendor variation was similar to inter-site variability. This variability includes differences in the actual implementation of the sequence.
引用
收藏
页码:345 / 355
页数:11
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