GENETIC-POLYMORPHISM OF HUMAN CYTOCHROME-P-450 (S)-MEPHENYTOIN 4-HYDROXYLASE - STUDIES WITH HUMAN AUTOANTIBODIES SUGGEST A FUNCTIONALLY ALTERED CYTOCHROME-P-450 ISOZYME AS CAUSE OF THE GENETIC DEFICIENCY

被引:48
作者
MEIER, UT [1 ]
MEYER, UA [1 ]
机构
[1] UNIV BASEL,BIOCTR,DEPT PHARMACOL,CH-4056 BASEL,SWITZERLAND
关键词
D O I
10.1021/bi00399a065
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:8466 / 8474
页数:9
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[1]   ELECTROPHORETIC CONCENTRATION OF MACROMOLECULES [J].
ALLINGTON, WB ;
CORDRY, AL ;
MCCULLOUGH, GA ;
MITCHELL, DE ;
NELSON, JW .
ANALYTICAL BIOCHEMISTRY, 1978, 85 (01) :188-196
[2]   HUMAN ANTI-ENDOPLASMIC RETICULUM AUTOANTIBODIES APPEARING IN A DRUG-INDUCED HEPATITIS ARE DIRECTED AGAINST A HUMAN-LIVER CYTOCHROME-P-450 THAT HYDROXYLATES THE DRUG [J].
BEAUNE, P ;
DANSETTE, PM ;
MANSUY, D ;
KIFFEL, L ;
FINCK, M ;
AMAR, C ;
LEROUX, JP ;
HOMBERG, JC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (02) :551-555
[3]   PURIFICATION OF A NEW CYTOCHROME-P-450 FROM HUMAN-LIVER MICROSOMES [J].
BEAUNE, P ;
FLINOIS, JP ;
KIFFEL, L ;
KREMERS, P ;
LEROUX, JP .
BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 840 (03) :364-370
[4]   ISOLATION AND SEQUENCE DETERMINATION OF A CDNA CLONE RELATED TO HUMAN CYTOCHROME-P-450 NIFEDIPINE OXIDASE [J].
BEAUNE, PH ;
UMBENHAUER, DR ;
BORK, RW ;
LLOYD, RS ;
GUENGERICH, FP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) :8064-8068
[5]  
BHOWN AS, 1983, METHOD ENZYMOL, V91, P450
[6]   IMMUNOQUANTIFICATION OF EPOXIDE HYDROLASE AND CYTOCHROME-P-450 ISOZYMES IN FETAL AND ADULT HUMAN-LIVER MICROSOMES [J].
CRESTEIL, T ;
BEAUNE, P ;
KREMERS, P ;
CELIER, C ;
GUENGERICH, FP ;
LEROUX, JP .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 151 (02) :345-350
[7]   CHARACTERIZATION OF A COMMON GENETIC-DEFECT OF CYTOCHROME-P-450 FUNCTION (DEBRISOQUINE-SPARTEINE TYPE POLYMORPHISM) - INCREASED MICHAELIS CONSTANT (KM) AND LOSS OF STEREOSELECTIVITY OF BUFURALOL 1'-HYDROXYLATION IN POOR METABOLIZERS [J].
DAYER, P ;
GASSER, R ;
GUT, J ;
KRONBACH, T ;
ROBERTZ, GM ;
EICHELBAUM, M ;
MEYER, UA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (01) :374-380
[8]   DEFECTIVE N-OXIDATION OF SPARTEINE IN MAN - NEW PHARMACOGENETIC DEFECT [J].
EICHELBAUM, M ;
SPANNBRUCKER, N ;
STEINCKE, B ;
DENGLER, HJ .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 16 (03) :183-187
[9]   PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY [J].
GREENWOOD, FC ;
HUNTER, WM .
BIOCHEMICAL JOURNAL, 1963, 89 (01) :114-&
[10]   MEPHENYTOIN-TYPE POLYMORPHISM OF DRUG OXIDATION - PURIFICATION AND CHARACTERIZATION OF A HUMAN-LIVER CYTOCHROME-P-450 ISOZYME CATALYZING MICROSOMAL MEPHENYTOIN HYDROXYLATION [J].
GUT, J ;
MEIER, UT ;
CATIN, T ;
MEYER, UA .
BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 884 (03) :435-447