EFFECTS OF EXCITATORY AND INHIBITORY AMINO-ACIDS ON NEURONAL DISCHARGES IN THE CULTURED SUPRACHIASMATIC NUCLEUS

被引：41

作者：

BOS, NPA ^{[1
]}

MIRMIRAN, M ^{[1
]}

机构：

[1] NETHERLANDS INST BRAIN RES,MEIBERGDREEF 33,1105 AZ AMSTERDAM,NETHERLANDS

来源：

BRAIN RESEARCH BULLETIN | 1993年 / 31卷 / 1-2期

关键词：

CIRCADIAN RHYTHMS; SUPRACHIASMATIC NUCLEUS; NEURONAL DISCHARGES; AMINO ACIDS; BIOLOGICAL CLOCK; MICROIONTOPHORESIS;

D O I：

10.1016/0361-9230(93)90012-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of amino acids on neuronal activity was studied microiontophoretically in the cultured suprachiasmatic nucleus (SCN). Three types of SCN neurons could be characterized: silent (glutamate responsive), irregular, and regular neurons. Glutamate excited about 70% of the regular and 60% of the irregular cells. GABA inhibited both the spontaneous and the glutamate-evoked activity of more than 90% of all three types of SCN neurons. MK-801 partially blocked glutamate responses. N-acetyl-aspartyl-glutamate (NAAG), a new neurotransmitter found in the retinohypothalamic fibers, directly increased firing rate and potentiated glutamate responses in the SCN neurons that were studied. These results indicate the potential significance of the amino acids in neuronal transmission within the biological clock.

引用

页码：67 / 72

页数：6

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