BONE-MARROW STROMAL CELLS ATTENUATE MITOXANTRONE CYTOTOXICITY AGAINST HL-60 LEUKEMIC-CELLS

被引：3

作者：

TAKAHASHI, A ^{[1
]}

YAMAMOTO, K ^{[1
]}

OKUMA, M ^{[1
]}

SASADA, M ^{[1
]}

机构：

[1] KYOTO UNIV, COLL MED TECHNOL, KYOTO 606, JAPAN

来源：

ANTI-CANCER DRUGS | 1992年 / 3卷 / 06期

关键词：

BONE MARROW STROMAL CELLS; HL-60 LEUKEMIA CELLS; MITOXANTRONE;

D O I：

10.1097/00001813-199212000-00014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We evaluated the effect of cultured human bone marrow (BM) stromal cells on the cytotoxicity of mitoxantrone (MIT) against the HL-60 leukemic cell line. BM-derived fibroblastoid cells (BMFC) suppressed colony formation of HL-60 cells in the absence of MIT. BMFC increased the survival of HL-60 colony-forming cells in the presence of 50 ng/ml MIT. A significant decrease in the drug concentration was not detected on BMFC. Our results suggest that BM stromal cells can modulate the antileukemic effect of an anticancer drug.

引用

页码：647 / 650

页数：4

共 17 条

[1] ACTIVATION OF PROGRAMMED CELL-DEATH (APOPTOSIS) BY CISPLATIN, OTHER ANTICANCER DRUGS, TOXINS AND HYPERTHERMIA [J].