ANGIOTENSIN-II FACILITATES THE POTASSIUM-EVOKED RELEASE OF H-3-NORADRENALINE FROM THE RABBIT HYPOTHALAMUS

被引：68

作者：

GARCIASEVILLA, JA ^{[1
]}

DUBOCOVICH, ML ^{[1
]}

LANGER, SZ ^{[1
]}

机构：

[1] SYNTHELABO,LAB ETUD RECH SCI,DEPT BIOL,58 RUE GLACIERE,F-75013 PARIS,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 56卷 / 1-2期

关键词：

Angiotensin II; Noradrenaline; Presynaptic angiotensin receptors; Rabbit hypothalamus; Saralasin; Transmitter release;

D O I：

10.1016/0014-2999(79)90449-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Angiotensin II facilitated in a concentration-dependent manner the potassium-evoked 3H-noradrenaline overflow from the rabbit hypothalamus. This effect which is probably mediated through presynaptic angiotensin facilitatory receptors on noradrenergic nerve terminals was blocked by the specific angiotensin receptor antagonist, saralasin. These results demonstrate that angiotensin II also facilitates the stimulation-evoked release of noradrenaline in the central nervous system. © 1979.

引用

页码：173 / 176

页数：4

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