CIRCADIAN VARIATION IN PLASMA 5-HYDROXYINDOLEACETIC ACID LEVEL DURING AND AFTER ALCOHOL-WITHDRAWAL - PHASE ADVANCES IN ALCOHOLIC PATIENTS COMPARED WITH NORMAL SUBJECTS

被引：19

作者：

SANO, H ^{[1
]}

SUZUKI, Y ^{[1
]}

YAZAKI, R ^{[1
]}

TAMEFUSA, K ^{[1
]}

OHARA, K ^{[1
]}

YOKOYAMA, T ^{[1
]}

MIYASATO, K ^{[1
]}

OHARA, K ^{[1
]}

机构：

[1] SEIMEI HOSP, FUJI, JAPAN

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1993年 / 87卷 / 04期

关键词：

ALCOHOLISM; 5-HYDROXYINDOLEACETIC ACID (5-HIAA); CIRCADIAN VARIATION; ALCOHOL WITHDRAWAL;

D O I：

10.1111/j.1600-0447.1993.tb03374.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Alcohol withdrawal symptoms in 19 male alcoholics were objectively evaluated and classified and circadian variation in their plasma 5-hydroxyindoleacetic acid (5-HIAA) concentrations was determined at 3 different intervals after cessation of drinking. Circadian variations in plasma 5-HIAA level exhibited phase advances in alcoholic patients compared with normal controls and were different depending on the severity of alcohol withdrawal symptoms. Plasma 5-HIAA in patients with delirium tremens showed significantly higher levels during the abstention period, possibly suggesting peculiarity in their serotonergic metabolism.

引用

页码：291 / 296

页数：6

共 34 条

[1] SEROTONIN IN BODY-FLUIDS - CHARACTERIZATION OF HUMAN PLASMATIC AND CEREBROSPINAL-FLUID POOLS BY MEANS OF A NEW HPLC METHOD [J].