AFRICAN SWINE FEVER VIRUS ENCODES A GENE WITH EXTENSIVE HOMOLOGY TO TYPE-II DNA TOPOISOMERASES

被引：24
|
作者：
BAYLIS, SA
DIXON, LK
VYDELINGUM, S
SMITH, GL
机构：
[1] UNIV OXFORD,SIR WILLIAM DUNN SCH PATHOL,S PARKS RD,OXFORD OX1 3RE,ENGLAND
[2] AFRC,INST ANIM HLTH,PIRBRIGHT LAB,WOKING GU24 0NF,SURREY,ENGLAND
来源：
JOURNAL OF MOLECULAR BIOLOGY | 1992年 / 228卷 / 03期
关键词：
AFRICAN SWINE FEVER VIRUS; ASFV; DNA TOPOISOMERASE-II; HOMOLOGY; CYTOPLASMIC REPLICATION;
D O I：
10.1016/0022-2836(92)90887-P
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nucleotide sequencing of a virulent African swine fever virus (ASFV) isolate (Malawi LIL20/1) identified an open reading frame of 1191 amino acid residues encoding a protein of 134·9 kDa. This gene mapped to the SalI i and j restriction endonuclease fragments of the ASFV genome. The predicted polypeptide was found to share 21·1% identity over a 1077 amino acid region with the human type II DNA topoisomerase. The sequence is compared to other type II DNA topoisomerases and the possible roles in ASFV replication are discussed. © 1992.
引用
收藏
页码：1003 / 1010
页数：8
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