Synthesis, identification, and investigation of the antibacterial effect of the new derivatives of sulfonamide Calix [4] Arenes based on aliphatic amines

The Calix arens are part of the Supramolecular family and designed as host molecules, so their synthesis has particular importance. In this research, Sulfonamide Calix [4] arene derivatives have been prepared from the reaction of the sulfonyl chloride Calix arene derivative in the presence of aliphatic amines type I and II. The structure of obtained derivatives was investigated using IR and (HNMR)-H-1 spectroscopy techniques. Antibacterial properties of these compounds were evaluated using MIC, MBC, and Disk Diffusion tests. The results revealed that derivatives have anti-bacterial properties, and substitution at the top rim of the ring is done correctly.