SEROTONIN RELEASE IS MODULATED BY PRESYNAPTIC AUTORECEPTORS

被引：205

作者：

CERRITO, F ^{[1
]}

RAITERI, M ^{[1
]}

机构：

[1] UNIV CATTOLICA,IST FARMACOL,I-00168 ROME,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 57卷 / 04期

关键词：

Serotonin antagonists; Serotonin autoreceptors; Serotonin release; Superfused synaptosomes;

D O I：

10.1016/0014-2999(79)90506-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The existence of presynaptic autoreceptors controlling the release of 5-hydroxytryptamine (5HT) from serotonergic nerve endings was investigated utilizing superfused hypthalamic synaptosomes. Extracellular 5HT reduced the high K+-induced release of previously accumulated 3H-5HT. The central 5HT receptor blocker methiothepin counteracted the inhibitory effect of 5HT. Other 5HT antagonists (cyproheptadine, methysergide and mianserin) were inactive and may therefore act preferentially at the postsynaptic receptors. © 1979.

引用

页码：427 / 430

页数：4

共 10 条

[1]

BOURGOIN S, 1977, J PHARMACOL EXP THER, V202, P519

[2] REGULATION OF [H-3]5-HYDROXYTRYPTAMINE RELEASE FROM RAT-BRAIN SLICES [J].