ENDOGENOUS DOPAMINE LOWERS THE DOPAMINE D2 RECEPTOR DENSITY AS MEASURED BY [H-3] RACLOPRIDE - IMPLICATIONS FOR POSITRON EMISSION TOMOGRAPHY OF THE HUMAN-BRAIN

被引：275

作者：

SEEMAN, P ^{[1
]}

GUAN, HC ^{[1
]}

NIZNIK, HB ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT PSYCHIAT,TORONTO M5S 1A8,ONTARIO,CANADA

来源：

SYNAPSE | 1989年 / 3卷 / 01期

关键词：

D O I：

10.1002/syn.890030113

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

引用

页码：96 / 97

页数：2

共 5 条

[1]

FARDE L, 1987, ARCH GEN PSYCHIAT, V44, P671

[2] SPECIFIC INVITRO AND INVIVO BINDING OF H-3-RACLOPRIDE - A POTENT SUBSTITUTED BENZAMIDE DRUG WITH HIGH-AFFINITY FOR DOPAMINE D-2 RECEPTORS IN THE RAT-BRAIN [J].

KOHLER, C ;

HALL, H ;

OGREN, SO ;

GAWELL, L .

BIOCHEMICAL PHARMACOLOGY, 1985, 34 (13) :2251-2259

[3] INVIVO RECEPTOR-BINDING - ATTEMPTS TO IMPROVE SPECIFIC-NON-SPECIFIC RATIOS [J].

NIEHOFF, DL ;

PALACIOS, JM ;

KUHAR, MJ .

LIFE SCIENCES, 1979, 25 (10) :819-826

[4] HUMAN-BRAIN D1 AND D2 DOPAMINE-RECEPTORS IN SCHIZOPHRENIA, ALZHEIMERS, PARKINSONS, AND HUNTINGTONS DISEASES [J].

SEEMAN, P ;

BZOWEJ, NH ;

GUAN, HC ;

BERGERON, C ;

REYNOLDS, GP ;

RIEDERER, P ;

JELLINGER, K ;

TOURTELLOTTE, WW ;

BIRD, ED .

NEUROPSYCHOPHARMACOLOGY, 1987, 1 (01) :5-15

[5] POSITRON EMISSION TOMOGRAPHY REVEALS ELEVATED D2 DOPAMINE-RECEPTORS IN DRUG-NAIVE SCHIZOPHRENICS [J].

WONG, DF ;

WAGNER, HN ;

TUNE, LE ;

DANNALS, RF ;

PEARLSON, GD ;

LINKS, JM ;

TAMMINGA, CA ;

BROUSSOLLE, EP ;

RAVERT, HT ;

WILSON, AA ;

TOUNG, JKT ;

MALAT, J ;

WILLIAMS, JA ;

OTUAMA, LA ;

SNYDER, SH ;

KUHAR, MJ ;

GJEDDE, A .

SCIENCE, 1986, 234 (4783) :1558-1563

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