COLCHICINE IN THE TREATMENT OF AA AND AL AMYLOIDOSIS

被引：63

作者：

LIVNEH, A ^{[1
]}

ZEMER, D ^{[1
]}

LANGEVITZ, P ^{[1
]}

SHEMER, J ^{[1
]}

SOHAR, E ^{[1
]}

PRAS, M ^{[1
]}

机构：

[1] TEL AVIV UNIV, SACKLER SCH MED, TEL AVIV, ISRAEL

来源：

SEMINARS IN ARTHRITIS AND RHEUMATISM | 1993年 / 23卷 / 03期

关键词：

AMYLOIDOSIS; COLCHICINE; AMYLOID-A; AMYLOID-L; FAMILIAL MEDITERRANEAN FEVER;

D O I：

10.1016/S0049-0172(05)80042-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Colchicine is an effective medication in the prevention and treatment of amyloidosis of familial Mediterranean fever. Its therapeutic effect depends on the stage of renal disease and the drug dose. To evaluate colchicine effect in AA amyloidosis of other diseases and in primary AL amyloidosis; the literature was reviewed. Findings were that (1) the effect of colchicine in reactive amyloidosis has not been methodically studied, but anecdotal reports suggest it may be beneficial; and (2) the results of studies and case reports on the effect of colchicine in primary amyloidosis are conflicting. Because a therapeutic effect of colchicine in primary and reactive amyloidosis has been shown in sporadic cases, a prospective, controlled, multicenter study assessing the effect of colchicine in all types of amyloidosis appears to be justified. Until such a study is available, the addition of colchicine in an appropriate dose to any therapeutic regimen of patients with AA or AL amyloidosis should be considered. © 1993 W.B. Saunders Company.

引用

页码：206 / 214

页数：9

共 75 条

[1] CYTOTOXIC DRUG-TREATMENT OF REACTIVE AMYLOIDOSIS IN RHEUMATOID-ARTHRITIS WITH SPECIAL REFERENCE TO RENAL-INSUFFICIENCY [J].