MALE-SPECIFIC METABOLISM OF SIMVASTATIN BY RAT-LIVER MICROSOMES

被引：0
|
作者：
UCHIYAMA, N
KAGAMI, Y
SAITOH, Y
OHTAWA, M
机构：
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 01期
关键词：
SIMVASTATIN; METABOLITE; IDENTIFICATION; RAT; LIVER MICROSOME; SEX DIFFERENCE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Simvastatin was more effectively metabolized by the liver microsomes of male rats than females. The sex difference appeared in the composition of the metabolites. Two male-specific metabolites were identified by NMR and mass spectrometry as 3''-hydroxy and 3',3''-dihydroxy-DELTA-4',5' derivatives of simvastatin.
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页码：236 / 238
页数：3
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