SUPPRESSION OF TUMOR-GROWTH IN-VIVO BY LOCAL AND SYSTEMIC 90K LEVEL INCREASE

被引:0
作者
JALLAL, B
POWELL, J
ZACHWIEJA, J
BRAKEBUSCH, C
GERMAIN, L
JACOBS, J
IACOBELLI, S
ULLRICH, A
机构
[1] MAX PLANCK INST BIOCHEM,DEPT BIOL MOLEC,D-82152 MARTINSRIED,GERMANY
[2] SUGEN INC,REDWOOD CITY,CA 94063
[3] UNIV G DANNUNZIO,CATTEDRA ONCOL MED,I-66100 CHIETI,ITALY
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D O I
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中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Expression levels of the immunostimulatory 90K antigen in mammary carcinoma, glioblastoma, and other tumor-derived cell lines inversely correlate with their tumorigenicity in athymic mice. Engineered enhancement of 90K expression results in significant (>80%) tumor growth inhibition, not by direct action on the tumor cell, but by stimulation of the residual cell-mediated immune defense of the nude mouse. Enhanced 90K level effects are both localized and systemic and involve induction of ICAM-1 and VCAM-1 in the tumor endothelium. The findings presented suggest a role for 90K as a molecular alarm signal for the body's cellular defense against pathogens, which in a subset of tumors is suppressed to allow cancer progression.
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页码:3223 / 3227
页数:5
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