CHLORPROMAZINE AND OTHER PSYCHOACTIVE DRUG-INDUCED ALTERATIONS OF A MEMBRANE-BOUND ENZYME IN RAT-BRAIN

被引：1
|
作者：
NAG, M
NANDI, N
机构：
[1] Enzyme Chemistry Department, Indian Institute of Chemical Biology, Calcutta, 700 032
来源：
BIOSCIENCE REPORTS | 1994年 / 14卷 / 03期
关键词：
CHLORPROMAZINE; IMIPRAMINE; LITHIUM; AMPHETAMINE; ALKALINE PHOSPHATASE;
D O I：
10.1007/BF01240246
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Psychoactive drugs like chlorpromazine (CPZ), imipramine, lithium and amphetamine in one way or another affect behaviour. The drug responses are presumably mediated by inducing a change in the activity of membrane bound enzymes. CPZ is very potent in inhibiting the alkaline phosphatase activity in rat brain. The combined effect of CPZ with other drugs shows that CPZ and imipramine together inhibit the enzyme activity significantly greater than the individual inhibition either by CPZ or by imipramine alone. Effective inhibition of the alkaline phosphatase activity with a single drug or combined drugs may lead to a change in neuronal permeability through glucocorticoids thereby affecting mood.
引用
收藏
页码：139 / 144
页数：6
相关论文
共 50 条
  • [1] EFFECT OF ETHANOL ON MEMBRANE-BOUND ENZYMES IN RAT-BRAIN
    LIEBERTHAL, S
    OLDFIELD, M
    SHANLEY, BC
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1979, 3 (03) : 277 - 277
  • [2] ACTIVITY OF MEMBRANE-BOUND ENZYMES IN AGED RAT-BRAIN
    LEELAVATHI, DE
    SMITH, RC
    ARZU, D
    AGE, 1979, 2 (04) : 130 - 130
  • [3] ARE SOLUBLE AND MEMBRANE-BOUND RAT-BRAIN ACETYLCHOLINESTERASE DIFFERENT
    ANDRES, C
    ELMOURABIT, M
    STUTZ, C
    MARK, J
    WAKSMAN, A
    NEUROCHEMICAL RESEARCH, 1990, 15 (11) : 1065 - 1072
  • [4] MEMBRANE-BOUND RNA IN SMOOTH MICROSOMES OF RAT-BRAIN
    BHATTACHARYYA, AK
    HORMONES, 1972, 3 (05): : 261 - +
  • [5] CHLORPROMAZINE - DIFFERENTIAL EFFECTS ON MEMBRANE-BOUND ENZYMES FROM RAT BRAIN
    ROBINSON, JD
    LOWINGER, J
    BETTINGER, B
    BIOCHEMICAL PHARMACOLOGY, 1968, 17 (06) : 1113 - +
  • [6] EFFECT OF AGING ON SOLUBLE AND MEMBRANE-BOUND ENZYMES IN RAT-BRAIN
    BAQUER, NZ
    HOTHERSALL, JS
    MCLEAN, P
    GREENBAUM, AL
    NEUROCHEMISTRY INTERNATIONAL, 1990, 16 (03) : 369 - 375
  • [7] SOLUBILIZATION OF MEMBRANE-BOUND OPIATE RECEPTOR FROM RAT-BRAIN
    CHO, TM
    YAMATO, C
    CHO, JS
    LOH, HH
    LIFE SCIENCES, 1981, 28 (23) : 2651 - 2657
  • [8] CYTOSOL AND MEMBRANE-BOUND KINASES DURING DEVELOPMENT IN RAT-BRAIN
    KINNIER, WJ
    CHUANG, DM
    COSTA, E
    FEDERATION PROCEEDINGS, 1979, 38 (03) : 263 - 263
  • [9] HYDROLYSIS OF MEMBRANE-BOUND DIACYLGLYCEROL BY LIPASE OF RAT-BRAIN MICROSOMES
    ROUSSEAU, A
    GATT, S
    ISRAEL JOURNAL OF MEDICAL SCIENCES, 1979, 15 (01): : 72 - 72
  • [10] DRUG-INDUCED ALTERATIONS OF 3-METHOXY-4-HYDROXYPHENYLETHANOL (MHPE) IN RAT-BRAIN
    WATERBURY, LD
    WENDEL, OT
    PEARCE, LA
    BIOCHEMICAL MEDICINE, 1973, 8 (01): : 61 - 71
12345