ANGIOTENSIN-II MEDIATES INTRACELLULAR SIGNALING IN VASCULAR SMOOTH-MUSCLE CELLS BY ACTIVATION OF TYROSINE-SPECIFIC PROTEIN-KINASES AND C-RAF-1

被引：27

作者：

BUTCHER, RD ^{[1
]}

SCHOLLMANN, C ^{[1
]}

MARME, D ^{[1
]}

机构：

[1] UNIV FREIBURG, INST MOLEC CELL BIOL, W-7800 FREIBURG, GERMANY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 196卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.2391

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiotensin II induces protein tyrosine kinase activation and apparent decreased electrophoretic mobility of the c-raf-1 serine/threonine protein kinase in cultured rat vascular smooth muscle cells. Tyrosine phosphorylation of at least 9 cellular proteins with molecular weights of 151, 131, 116, 110, 90, 65, 62, 60, 52 kd was induced in a time- and concentration-dependent manner, and included a serine/threonine protein kinase. The phosphotyrosine containing proteins differed from those induced by PDGF BB or AB. Angiotensin II by itself was shown not to act as a mitogen in cultured smooth muscle cells. © 1993 Academic Press. All rights reserved.

引用

页码：1280 / 1287

页数：8

共 27 条

[1] CLONING AND CHARACTERIZATION OF A HUMAN ANGIOTENSIN-II TYPE-1 RECEPTOR [J].

BERGSMA, DJ ;

ELLIS, C ;

KUMAR, C ;

NUTHULAGANTI, P ;

KERSTEN, H ;

ELSHOURBAGY, N ;

GRIFFIN, E ;

STADEL, JM ;

AIYAR, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 183 (03) :989-995

[2]

CLAESSONWELSH L, 1989, J BIOL CHEM, V264, P1742

[3] FOCUS ON DISEASE - ESSENTIAL-HYPERTENSION - RATIONAL PHARMACOTHERAPY [J].

CONNELL, JMC .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1986, 7 (10) :412-418

[4] SIMILAR EFFECTS OF PLATELET-DERIVED GROWTH-FACTOR AND EPIDERMAL GROWTH-FACTOR ON THE PHOSPHORYLATION OF TYROSINE IN CELLULAR PROTEINS [J].

COOPER, JA ;

BOWENPOPE, DF ;

RAINES, E ;

ROSS, R ;

HUNTER, T .

CELL, 1982, 31 (01) :263-273

[5]

COOPER JA, 1983, METHOD ENZYMOL, V99, P387

[6] INOSITOL 1,4,5-TRISPHOSPHATE ACTIVATES A CHANNEL FROM SMOOTH-MUSCLE SARCOPLASMIC-RETICULUM [J].

EHRLICH, BE ;

WATRAS, J .

NATURE, 1988, 336 (6199) :583-586

[7]

FORCE T, 1991, J BIOL CHEM, V266, P6650

[8]

FRACKELTON AR, 1984, J BIOL CHEM, V259, P7909

[9] PERTUSSIS TOXIN INHIBITS ANGIOTENSIN II-MEDIATED PHOSPHATIDYL-INOSITOL BREAKDOWN AND ADP-RIBOSYLATES A 40-KD PROTEIN IN CULTURED SMOOTH-MUSCLE CELLS [J].

GAUL, G ;

GIERSCHIK, P ;

MARME, D .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 150 (02) :841-847

[10] ANGIOTENSIN-II INDUCES HYPERTROPHY, NOT HYPERPLASIA, OF CULTURED RAT AORTIC SMOOTH-MUSCLE CELLS [J].

GEISTERFER, AAT ;

PEACH, MJ ;

OWENS, GK .

CIRCULATION RESEARCH, 1988, 62 (04) :749-756

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