INOSITOL TRISPHOSPHATE AND CALCIUM SIGNALING

被引：6433
作者：
BERRIDGE, MJ
机构：
[1] AFRC Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, Cambridge CB23EJ, Downing Street
来源：
NATURE | 1993年 / 361卷 / 6410期
关键词：
D O I：
10.1038/361315a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels displays the regenerative process of calcium-induced calcium release responsible for the complex spatiotemporal patterns of calcium waves and oscillations. Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling.
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页码：315 / 325
页数：11
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