EFFECT OF LOW-DOSE HEPARIN ON URINARY ALBUMIN EXCRETION IN INSULIN-DEPENDENT DIABETES-MELLITUS

被引：91

作者：

MYRUP, B

HANSEN, PM

JENSEN, T

KOFOEDENEVOLDSEN, A

FELDTRASMUSSEN, B

GRAM, J

KLUFT, C

JESPERSEN, J

DECKERT, T

机构：

[1] NOVO NORDISK AS,BAGSVAERD,DENMARK

[2] S JUTLAND UNIV CTR,THROMBOSIS RES INST,ESBJERG,DENMARK

[3] GAUBIUS LAB,LEIDEN,NETHERLANDS

来源：

LANCET | 1995年 / 345卷 / 8947期

关键词：

D O I：

10.1016/S0140-6736(95)90403-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p=0.04 and p=0.004). The mechanism and clinical relevance is unknown but deserve further attention.

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收藏

页码：421 / 422

页数：2

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