VITAMIN-E DIETARY SUPPLEMENTATION INHIBITS TRANSFORMING GROWTH-FACTOR BETA-1 GENE-EXPRESSION IN THE RAT-LIVER

被引:128
作者
PAROLA, M
MURACA, R
DIANZANI, I
BARRERA, G
LEONARDUZZI, G
BENDINELLI, P
PICCOLETTI, R
POLI, G
机构
[1] UNIV TURIN,INST CLIN PEDIAT,I-10125 TURIN,ITALY
[2] CNR,CTR IMMUNOGENET & ONCOL SPERIMENTALE,TURIN,ITALY
[3] UNIV MILAN,IST PATOL GEN,I-20122 MILAN,ITALY
关键词
LIVER FIBROSIS; TGF-BETA-1; ALPHA-2-(I)-PROCOLLAGEN; VITAMIN-E;
D O I
10.1016/0014-5793(92)81290-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Overexpression of transforming growth factor-beta-1 (TGF-beta-1) and increased transcription of pro-collagen type I, are known to represent major events implicated in the development of liver fibrosis under either experimental or clinical conditions. Here we report that long-term dietary vitamin E supplementation in animals undergoing an experimental model of liver fibrosis (induced by chronic treatment of rats with carbon tetrachloride) results in a net inhibition of both hepatic TGF-beta-1 and alpha-2 (I) procollagen mRNA levels. Moreover, of striking interest is the observation that vitamin E supplementation per so down-modulates basal levels of TGF-beta-1 mRNA in the liver of untreated animals, suggesting that a dietary regimen rich in vitamin E may potentially interfere with both the initiation and progression of the fibrosclerotic processes.
引用
收藏
页码:267 / 270
页数:4
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