ACID-ASPIRATION PROPHYLAXIS BY USE OF PREOPERATIVE ORAL-ADMINISTRATION OF CIMETIDINE

被引：43
|
作者：
COOMBS, DW
HOOPER, D
COLTON, T
机构：
来源：
ANESTHESIOLOGY | 1979年 / 51卷 / 04期
关键词：
D O I：
10.1097/00000542-197910000-00018
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
In a double-blind study, a single oral dose of 300 mg cimetidine, administered one and a half to five hours preoperatively, significantly increased (P<0.001) the gastric-fluid pH (5.11 ± 2.51) compared with placebo (2.45 ± 1.52), and significantly decreased (P<0.001) the number of patients at risk for serious pulmonary damage if aspiration occurs (25% of cimetidine-treated patients had pH values of less than 2.5) compared with placebo (75% of patients). Gastric-fluid volume was not significantly altered.
引用
收藏
页码：352 / 356
页数：5
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