ENDOGENOUS XENOPUS-OOCYTE CA-CHANNELS ARE REGULATED BY PROTEIN KINASE-A AND KINASE-C

被引：54

作者：

BOURINET, E ^{[1
]}

FOURNIER, F ^{[1
]}

NARGEOT, J ^{[1
]}

CHARNET, P ^{[1
]}

机构：

[1] CTR RECH BIOCHIM MACROMOLEC,CNRS,ROUTE MENDE,BP 5051,F-34033 MONTPELLIER,FRANCE

来源：

FEBS LETTERS | 1992年 / 299卷 / 01期

关键词：

CALCIUM CHANNEL; OOCYTE; PHOSPHORYLATION; PROTEIN KINASE-A; PROTEIN KINASE-C;

D O I：

10.1016/0014-5793(92)80087-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium entry into Xenopus oocyte occurs mainly through voltage-dependent calcium channels. These channels were characterized as belonging to a particular type of calcium channel insensitive to dihydropyridines, omega-conotoxin, and Agelenopsis aperta venom, but blocked by divalent cations (Co, Cd, Ni). Intracellular injection of cAMP, or bath application of phorbol ester, induced a marked increase in calcium current amplitude and a slowing of the inactivation time-course. Despite their different pharmacology, endogenous calcium channels, like cardiac or neuronal calcium channels, could be thus regulated by protein kinases A and C.

引用

页码：5 / 9

页数：5

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