ENDOGENOUS XENOPUS-OOCYTE CA-CHANNELS ARE REGULATED BY PROTEIN KINASE-A AND KINASE-C

被引:54
|
作者
BOURINET, E [1 ]
FOURNIER, F [1 ]
NARGEOT, J [1 ]
CHARNET, P [1 ]
机构
[1] CTR RECH BIOCHIM MACROMOLEC,CNRS,ROUTE MENDE,BP 5051,F-34033 MONTPELLIER,FRANCE
关键词
CALCIUM CHANNEL; OOCYTE; PHOSPHORYLATION; PROTEIN KINASE-A; PROTEIN KINASE-C;
D O I
10.1016/0014-5793(92)80087-W
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Calcium entry into Xenopus oocyte occurs mainly through voltage-dependent calcium channels. These channels were characterized as belonging to a particular type of calcium channel insensitive to dihydropyridines, omega-conotoxin, and Agelenopsis aperta venom, but blocked by divalent cations (Co, Cd, Ni). Intracellular injection of cAMP, or bath application of phorbol ester, induced a marked increase in calcium current amplitude and a slowing of the inactivation time-course. Despite their different pharmacology, endogenous calcium channels, like cardiac or neuronal calcium channels, could be thus regulated by protein kinases A and C.
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页码:5 / 9
页数:5
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