ACUTE EFFECTS OF ZIMELIDINE AND ALAPROCLATE, 2 INHIBITORS OF SEROTONIN UPTAKE, ON NEURO-ENDOCRINE FUNCTION

被引：14
作者：
SYVALAHTI, E
ENEROTH, P
ROSS, SB
机构：
[1] Erkka Syvälahti, M.D., is Associate Professor, Department of Psychiatry, University of Turku
[2] S.B. Ross, Ph.D., is Professor, Research Laboratories, Astra Pharmaceuticals AB, Södertälje
来源：
PSYCHIATRY RESEARCH | 1979年 / 1卷 / 02期
关键词：
Alaproclate; antidepressants; blood platelets; cortisol; pituitary hormones; serotonin; zimelidine;
D O I：
10.1016/0165-1781(79)90051-9
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The accumulation of 14C-5-hydroxytryptamine in human platelets in vitro and plasma levels of a number of hypophyseal hormones and cortisol in healthy male volunteers were determined after acute oral administration of zimelidine and alaproclate, two selective inhibitors of serotonin (5-HT) uptake. Alaproclate (100 mg) significantly inhibited the accumulation of 14C-5-HT by 42% at 90 minutes but showed no significant effect at 4 hours. At 200 mg the decrease in the accumulation was 55% after 90 minutes and 31% after 4 hours. Zimelidine (200 mg) caused a 72% decrease at 90 minutes and 73% at 4 hours. Plasma levels of prolactin, growth hormone, luteinizing hormone, follicle stimulating hormone, and thyroid stimulating hormone remained unchanged after zimelidine and alaproclate, and the levels were comparable to those after placebo. A physiological decline of plasma cortisol levels was noted in the morning during the test period of 4 hours, but there were slight differences in the secretory pattern after the different drugs used. © 1979.
引用
收藏
页码：111 / 120
页数：10
相关论文
共 20 条
  • [1] Fuxe, Ogren, Everitt, Agnati, Eneroth, Gustafsson, Jonsson, Skett, Holm, The effect of antidepressant drugs of the imipramine type on various monoamine systems and their relations to changes in behaviour and neuroendocrine function, Depressive Disorders, (1977)
  • [2] Hyyppa, Falck, Gavert, Kytomaki, Rautakorpi, Syvalahti, L-tryptophan administration in man: Effects on gonadotrophin, growth hormone and cortisol secretion and on sexual motivation, Monographs in Neural Sciences, (1976)
  • [3] Hyyppa, Jolma, Langvik, Kytomaki, Syvalahti, L-trytophan and neuroendocrine regulation in neurologic patients: Hormone responses to L-trytophan loading in patients with hypothalamic lesion, Psychoneuroendocrinology, 2, (1977)
  • [4] Kamberi, Mical, Porter, Effect of anterior perfusion and intraventricular injection of catecholamines and indoleamines on LH release, Endocrinology, 87, (1970)
  • [5] Kamberi, Mical, Porter, Effects of melatonin and serotonin on the release of FSH and prolactin, Endocrinology, 88, (1971)
  • [6] Krieger, Endocrine processes and serotonin, Serotonin in Health and Disease, 3, (1978)
  • [7] Lindberg, Thorberg, Bengtsson, Renyi, Ross, Ogren, Inhibitors of neuronal monoamine uptake. 2. Selective inhibition of 5-hydroxytryptamine uptake by α-amino acid esters of phenethyl alcohols, Journal of Medicinal Chemistry, 21, (1978)
  • [8] Lingjaerde, Effect of doxepin on uptake and efflux of serotonin in human blood platelets in vitro, Psychopharmacologia, 47, (1976)
  • [9] MacIndoe, Turkington, Stimulation of human prolactin secretion by intravenous infusion of 1-tryptophan, Journal of Clinical Investigation, 52, (1973)
  • [10] Montgomery, McAuley, Rani, Montgomery, A double blind comparison of antidepressant efficacy of zimelidine. A new 5-HT uptake inhibitor with amitriptyline, Abstracts of 7th International Congress of Pharmacology, (1978)
12