TREATMENT OF ADVANCED CHRONIC LYMPHOCYTIC-LEUKEMIA BY FLUDARABINE - RESULTS OF A CLINICAL PHASE-II STUDY

被引：77

作者：

HIDDEMANN, W ^{[1
]}

ROTTMANN, R ^{[1
]}

WORMANN, B ^{[1
]}

THIEL, A ^{[1
]}

ESSINK, M ^{[1
]}

OTTENSMEIER, C ^{[1
]}

FREUND, M ^{[1
]}

BUCHNER, T ^{[1
]}

VANDELOO, J ^{[1
]}

机构：

[1] MED SCH HANNOVER,DEPT HEMATOL & ONCOL,HANNOVER,GERMANY

来源：

ANNALS OF HEMATOLOGY | 1991年 / 63卷 / 01期

关键词：

CHRONIC LYMPHOCYTIC LEUKEMIA; FLUDARABINE; NERVOUS-SYSTEM TOXICITY; DEOXYCYTIDINE KINASE; 9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE; CHLORAMBUCIL; PREDNISONE; LYMPHOMA; TRIAL; THERAPY;

D O I：

10.1007/BF01714952

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a clinical phase-II study fludarabine phosphate was given to 20 patients with advanced chronic lymphocytic leukemia who had failed on prior conventional therapy. Fludarabine was administered at a dose of 25 mg/m2/d for 5 days. Treatment cycles were repeated every 4 weeks until maximal response, followed by two cycles for consolidation. Four of the 20 patients achieved complete remission and seven patients partial remission, resulting in an overall response rate of 55% (11/20). fludarabine therapy was well tolerated, with mild myelosuppression and secondary infections comprising the predominant side effects. These data warrant further confirmation and a randomized comparison of fludarabine with established regimens, which is currently underway.

引用

页码：1 / 4

页数：4

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