ANTIMALARIALS . UNSATURATION IN CHLOROQUINE SIDE CHAIN AND ANTIMALARIAL ACTIVITY

被引：13

作者：

SINGH, T

STEIN, RG

BIEL, JH

机构：

[1] Research Laboratories, Aldrich Chemical Company, Inc., Milwankee

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1021/jm00303a005

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six chloroquine derivatives with unsaturation in the diamine side chain in the form of acetylenic and cis and trans ethylenic bonds have been prepared and their antimalarial activity has been compared with that of chloroquine against Plasmodium berghei in mice. Some of these were found to be more potent and less toxic than chloroquine. © 1969, American Chemical Society. All rights reserved.

引用

页码：368 / &

共 8 条

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