THE INSULIN-ELICITED 160-KDA PHOSPHOTYROSINE PROTEIN IN MOUSE ADIPOCYTES IS AN INSULIN-RECEPTOR SUBSTRATE-1 - IDENTIFICATION BY CLONING

被引：50
作者：
KELLER, SR
AEBERSOLD, R
GARNER, CW
LIENHARD, GE
机构：
[1] UNIV BRITISH COLUMBIA,BIOMED RES CTR,VANCOUVER V6T 1W5,BC,CANADA
[2] TEXAS TECH UNIV,HLTH SCI CTR,DEPT BIOCHEM & MOLEC BIOL,LUBBOCK,TX 79430
[3] UNIV BRITISH COLUMBIA,DEPT BIOCHEM,VANCOUVER V6T 1W5,BC,CANADA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1172卷 / 03期
关键词：
INSULIN SIGNALING; INSULIN RECEPTOR SUBSTRATE-1; ADIPOCYTE; 3T3-L1;
D O I：
10.1016/0167-4781(93)90222-Y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Insulin elicits the tyrosine phosphorylation of one or more proteins of 160-185 kDa in many cell types. Peptide sequences, obtained from this protein purified from mouse 3T3-L1 adipocytes (pp160), were used as the basis for cloning its cDNA. pp160 is highly homologous to the insulin receptor substrate 1, previously cloned from rat liver. Thus, this component of the insulin signaling pathway is the same in adipocytes and in liver.
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页码：323 / 326
页数：4
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