CYTOTOXIC EFFECTS OF LEUKOCYTES TRIGGERED BY COMPLEMENT BOUND TO TARGET CELLS

被引：89

作者：

PERLMANN, P

PERLMANN, H

MULLEREV.HJ

MANNI, JA

机构：

[1] Wenner-Gren Institute for Experimental Biology, University of Stockholm, Stockholm

[2] Department of Experimental Pathology, Scripps Clinic and Research Foundation, San Diego

来源：

SCIENCE | 1969年 / 163卷 / 3870期

关键词：

D O I：

10.1126/science.163.3870.937

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chromium-51-labeled chicken erythrocytes (E), treated with rabbit anti-Forssman antibody (A) and the first four (C1-4) or the first seven (C1-7) components of human complement (C), released isotope upon exposure to human leukocytes. Isotope release from EAC1-7 cells proceeded more rapidly and was more extensive than that from EAC1-3 cells. Lysis of these cells was suppressed by pretreatment of leukocytes with antimycin A. Monocyte-enriched leukocyte preparations affected both types of target cell-complement intermediates, whereas purified lymphocytes lysed EACI-7 cells but not EAC1-3 cells.

引用

页码：937 / &

共 33 条

[1] ISOLATION AND SELECTED PROPERTIES OF BLOOD MONOCYTES [J].