AUTOMATED COLORIMETRIC ANALYSIS OF ETHINYL ESTRADIOL AND MESTRANOL IN PHARMACEUTICAL TABLETS

被引：13

作者：

BEYER, WF

机构：

[1] Control Division, Upjohn Company, Kalamazoo, Michigan

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 08期

关键词：

Automated analysis—tablets; steroid mixtures; Colorimetric analysis—spectrophotometer; Diagram—automated apparatus; Mestranol—analysis;

D O I：

10.1002/jps.2600570831

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An automated colorimetric procedure is described for the determination of ethinyl estradiol and ethinyl estradiol‐3‐methyl ether in pharmaceutical tablets. Chloroform solutions of the estrogen are automatically extracted with alcohol–sulfuric acid and analyzed at a rate of 20 samples/hr. The relative standard deviation of repetitive sampling of tablet extracts was less than 1 percent, and Beer's law was obeyed over the range of 0.40–8.00 mcg./ml. of sample solution. The procedure is applicable to unit dosage assays and to assays requiring composite samples of pulverized tablets or numerous whole tablets. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1415 / &

共 8 条

[1]

ANDERSON RA, 1967, AUTOMATION ANALYTICA, P267

[2] A NOTE ON SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF NORETHYNODREL AND MESTRANOL IN TABLETS [J].