THE RNA-POLYMERASE-II CARBOXY-TERMINAL DOMAIN - LINKS TO A BIGGER AND BETTER HOLOENZYME

被引：19

作者：

EMILI, A ^{[1
]}

INGLES, CJ ^{[1
]}

机构：

[1] UNIV TORONTO, CHARLES H BEST INST, DEPT MOLEC & MED GENET, TORONTO, ON M5G 1L6, CANADA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0959-437X(95)80009-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The largest subunit of eukaryotic RNA polymerase II has an unusual tandemly repeated heptapeptide sequence at its carboxyl terminus. The function of this evolutionarily conserved carboxy-terminal domain is unknown; however, new evidence links it to the formation of a large multi-component RNA polymerase II complex possessing enhanced transcriptional initiation properties. The existence of a pre-assembled RNA polymerase II 'holoenzyme' in the cell calls into question the long held view of transcription initiation as an ordered multi-step process.

引用

页码：204 / 209

页数：6

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