INFLUENCE OF ORGANIC BRAIN-SYNDROME ON LONG-TERM OUTCOME AFTER ISCHEMIC STROKE

Long-term outcome at a qualifying date compared to acute prognosis was investigated up to 5.5 years in 86.6% (n = 957) of a cohort of 1 105 patients admitted to hospital with an acute ischaemic stroke. Especially the influence of organic brain syndromes (OBS) on long-term prognosis of ischaemic stroke was evaluated. Kaplan-Meier-survival indices were calculated. Patients with OBS predominantly showed lacunar ischaemic strokes. Despite of better acute prognosis of the subgroup with OBS (lower mortality within 30 days, less risk factors and complicating diseases) long-term prognosis was worse even compared with age adjusted stroke patients without OBS. So for instance 90% of stroke patients without OBS survive only up to 12 days, in contrast 90% of the patients with OBS survive up to 33 days, but 50% of the patients without OBS survive up to 507 days and 50% with OBS only up to 252 days. So OBS seems to be a marker for worse long-term prognosis of patients with ischaemic stroke.