LIPASE-CATALYZED AMINOLYSIS OF ETHYL PROPIOLATE AND ACRYLIC ESTERS - SYNTHESIS OF CHIRAL ACRYLAMIDES

被引：60

作者：

PUERTAS, S ^{[1
]}

BRIEVA, R ^{[1
]}

REBOLLEDO, F ^{[1
]}

GOTOR, V ^{[1
]}

机构：

[1] UNIV OVIEDO,FAC QUIM,DEPT QUIM ORGAN & INORGAN,E-33071 OVIEDO,SPAIN

来源：

TETRAHEDRON | 1993年 / 49卷 / 19期

关键词：

AMINOLYSIS; LIPASE; ENANTIOSELECTIVITY; PROPIOLAMIDES; ACRYLAMIDES;

D O I：

10.1016/S0040-4020(01)89914-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Candida cylindracea lipase is a useful catalyst for the preparation of propiolamides, Candida antarctica lipase efficiently catalyzes the aminolysis of different acrylic esters and aliphatic amines; if racemic amines are used, the corresponding optically active acrylic amide is obtained in moderate-high enantiomeric excess.

引用

页码：4007 / 4014

页数：8

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