A QSAR APPROACH TO THE STUDY OF STRUCTURAL REQUIREMENTS OF MUSCARINIC RECEPTOR LIGANDS .1. AGONISTS

被引:4
作者
PRATESI, P
CALIENDO, G
SILIPO, C
VITTORIA, A
机构
[1] UNIV MILAN,FAC PHARM,I-20122 MILAN,ITALY
[2] NAPLES UNIV,DEPT PHARMACEUT & TOXICOL CHEM,I-80138 NAPLES,ITALY
来源
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS | 1992年 / 11卷 / 01期
关键词
CORRELATION ANALYSIS; MUSCARINIC RECEPTORS; AGONISTS;
D O I
10.1002/qsar.19920110102
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
This report examines the development of quantitative structure-activity relationships (QSAR) in the analysis of ligand muscarinic receptor interactions. Several sets of agonists acting on different tissues (distinct receptor subtypes) are considered. It is shown that QSAR may represent a suitable tool to increase the general understanding of the nature of ligand interactions at receptor sites. The points discussed in the paper are to draw attention to the development of correlations between biological affinity constants and molecular architecture of the ligands which are essential for deriving refined concepts on the topology of muscarinic receptor sites.
引用
收藏
页码:1 / 17
页数:17
相关论文
共 60 条
[31]   METHOCTRAMINE, A POLYMETHYLENE TETRAAMINE, DIFFERENTIATES 3 SUBTYPES OF MUSCARINIC RECEPTOR IN DIRECT BINDING-STUDIES [J].
MICHEL, AD ;
WHITING, RL .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 145 (01) :61-66
[32]   DIRECT BINDING-STUDIES ON ILEAL AND CARDIAC MUSCARINIC RECEPTORS [J].
MICHEL, AD ;
WHITING, RL .
BRITISH JOURNAL OF PHARMACOLOGY, 1987, 92 (04) :755-767
[33]  
MICHELETTI R, 1987, J PHARMACOL EXP THER, V241, P628
[34]  
MIYAGAWA M, 1982, FARMACO, V37, P7977
[35]  
NEMETHY G, 1962, J PHYS CHEM-US, V66, P1173
[36]   PRIMARY STRUCTURE AND BIOCHEMICAL-PROPERTIES OF AN M2 MUSCARINIC RECEPTOR [J].
PERALTA, EG ;
WINSLOW, JW ;
PETERSON, GL ;
SMITH, DH ;
ASHKENAZI, A ;
RAMACHANDRAN, J ;
SCHIMERLIK, MI ;
CAPON, DJ .
SCIENCE, 1987, 236 (4801) :600-605
[37]  
PRATESI P, 1986, FARMACO, V41, P335
[38]  
PRATESI P, 1982, FARMACO-ED SCI, V37, P398
[39]  
PRATESI P, 1981, FARMACO-ED SCI, V36, P749
[40]  
PRATESI P, 1979, FARMACO-ED SCI, V34, P579