STABILITY OF LIPOSOMES INVIVO AND INVITRO IS PROMOTED BY THEIR CHOLESTEROL CONTENT AND THE PRESENCE OF BLOOD-CELLS

被引：218
作者：
GREGORIADIS, G
DAVIS, C
机构：
[1] Division of Clinical Sciences, Clinical Research Centre, Harrow, Middx HA1 3UJ, Watford Road
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 04期
关键词：
D O I：
10.1016/0006-291X(79)92148-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The stability of liposomes containing 6-carboxyfluorescein or β-fructofuranosidase was measured in the blood of injected animals and also invitro in the presence of whole blood or serum. Stability, monitored by measuring changes in the permeability of liposomes to 6-carboxyfluorescein and sucrose, was found to depend on the cholesterol content of liposomes and it was promoted by the presence of blood cells. © 1979.
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页码：1287 / 1293
页数：7
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