EVIDENCE THAT THE STIMULATORY EFFECT OF NEUROTENSIN ON DOPAMINE RELEASE IN RAT NUCLEUS-ACCUMBENS SLICES IS INDEPENDENT OF DOPAMINE D2-RECEPTOR ACTIVATION

被引：12
|
作者：
REYNEKE, L
RUSSELL, VA
TALJAARD, JJF
机构：
[1] MRC Research Unit for the Neurochemistry of Mental Diseases, Department of Chemical Pathology, University of Stellenbosch, Tygerberg
来源：
BRAIN RESEARCH | 1990年 / 534卷 / 1-2期
基金：
英国医学研究理事会;
关键词：
Acetylcholine release; Dopamine release; Neurotensin; Nucleus accumbens; Quinpirole; Sulpiride;
D O I：
10.1016/0006-8993(90)90128-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurotensin (NT, 10-9 M and 10-7 M) increased the electrically stimulated release of [3H]dopamine (DA) in rat nucleus accumbens slices. This effect was not altered by activation of DA D2-receptors with high or low concentrations of quinpirole (10-6 M and 10-8 M) or blockade of DA D2-receptors with near maximal concentrations of sulpiride (10-6 M and 10-5 M). The sulpiride-mediated increase in [3H]DA release and the release induced by NT were additive. These results suggest that NT functions independently of DA D2-receptor activation to modulate DA release in the nucleus accumbens. NT did not modulate the simultaneous release of [14C]acetylcholine. © 1990.
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页码：188 / 194
页数：7
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