ASSOCIATION OF TYPE-I PHOSPHATIDYLINOSITOL KINASE-ACTIVITY WITH MUTATIONALLY ACTIVATED FORMS OF HUMAN PP60C-SRC

被引：29
作者：
CHAN, TO
TANAKA, A
BJORGE, JD
FUJITA, DJ
机构：
[1] UNIV CALGARY,CTR MED SCI,DEPT MED BIOCHEM,CELL REGULAT GRP,CALGARY T2N 4N1,ALBERTA,CANADA
[2] CTR MOLEC MED & IMMUNOL,NEWARK,NJ 07103
来源：
MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 06期
关键词：
D O I：
10.1128/MCB.10.6.3280
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chicken embryo fibroblast cells overexpressing activated mutant forms of human ppd60c-src, but not those overexpressing normal human pp60c-src, exhibited high levels of type I phosphatidylinositol (PI) kinase activity associated with pp60c-src. Levels of PI kinase activity were positively correlated with src tyrosine protein kinase activity and not with absolute levels of pp60c-src. Our results suggest that a linkage exists between certain forms of pp60c-src and the PI signal transduction pathway.
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页码：3280 / 3283
页数：4
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