INCREASED ATRIAL-NATRIURETIC-PEPTIDE BINDING-SITES IN THE RAT SUBFORNICAL ORGAN AFTER WATER-DEPRIVATION

被引：42
作者：
SAAVEDRA, JM [1 ]
ISRAEL, A [1 ]
KURIHARA, M [1 ]
机构：
[1] NIMH, CLIN SCI LAB,CLIN PHARMACOL SECT, PRECLIN NEUROPHARMACOL UNIT,BLDG 10, ROOM 2D46, BETHESDA, MD 20892 USA
来源：
ENDOCRINOLOGY | 1987年 / 120卷 / 01期
关键词：
D O I：
10.1210/endo-120-1-426
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Binding sites for rat atrial natriuretic peptide (99-126) were localized and quantified in the subfornical organ and choroid plexus of control and water-deprived rats. Brain sections were analyzed after incubation with 125I-rat atrial natriuretic peptide (99-126), autoradiography, computerized microdensitometry and comparison to 125I-standards. Higher numbers of atrial natriuretic peptide binding sites were present in both the subfornical organ and the choroid plexus after 4 days of water deprivation. Our results indicate a central role for atrial natriuretic peptide in the regulation of water balance.
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页码：426 / 428
页数：3
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