LOW PREVALENCE OF PRECORE MUTATIONS IN HEPATITIS-B VIRUS-DNA IN FULMINANT-HEPATITIS TYPE-B IN FRANCE

被引：52
作者：
FERAY, C
GIGOU, M
SAMUEL, D
BERNUAU, J
BISMUTH, H
BRECHOT, C
机构：
[1] INST PASTEUR,F-75724 PARIS 15,FRANCE
[2] HOP BEAUJON,UNITE HEPATOL,CLICHY,FRANCE
[3] CHU NECKER,INSERM,U370,PARIS,FRANCE
[4] HOP LAENNEC,UNITE HEPATOL,PARIS,FRANCE
来源：
JOURNAL OF HEPATOLOGY | 1993年 / 18卷 / 01期
关键词：
POLYMERASE CHAIN REACTION; DIRECT SEQUENCING;
D O I：
10.1016/S0168-8278(05)80019-4
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The presence of mutants of the precore region of the hepatitis B virus genome was investigated in French patients with fulminant hepatitis. Only one of the 10 subjects had a detectable mutation by direct sequencing. On the other hand, 2/10 and 3/10 had evidence of coinfection by hepatitis D virus and hepatitis C virus. These results indicate that the precore stop mutation at codon 28 is not a general condition in fulminant hepatitis B and might reflect epidemiological factors.
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页码：119 / 122
页数：4
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