INTERACTION OF INTERLEUKIN-2 AND INTERLEUKIN-4 DURING LAK CELL GENERATION

被引：0
|
作者：
INDROVA, M
JANDLOVA, T
BUBENIK, J
机构：
来源：
FOLIA BIOLOGICA | 1992年 / 38卷 / 01期
关键词：
INTERLEUKIN-2; INTERLEUKIN-4; LAK CELLS;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Immunoregulatory lymphokines IL-2 and IL-4 produced by IL-2- and IL-4-cDNA-transformed somatic cells were used for LAK cell generation. The cytolytic effect of LAK cells activated for 3 days with IL-2 and measured by Cr-51 release of three types of target cells, YAC-1 (NK-sensitive), C1498 (NK-resistant) and X63-Ag8.653 (plasmocytoma cell line utilized for insertion of the IL-2 and Il-4 genes), was significantly depressed by adding IL-4 during the activation period.
引用
收藏
页码：1 / 9
页数：9
相关论文
共 50 条
  • [31] INTERLEUKIN-3 INHIBITS THE GENERATION OF NONSPECIFIC KILLERS BY INTERLEUKIN-2
    MCADAM, AJ
    YEH, KY
    PULASKI, BA
    FRELINGER, JG
    LORD, EM
    JOURNAL OF IMMUNOTHERAPY, 1993, 14 (04): : 293 - 297
  • [32] Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases
    W Klein
    A Tromm
    T Griga
    H Fricke
    C Folwaczny
    M Hocke
    K Eitner
    M Marx
    N Duerig
    JT Epplen
    Genes & Immunity, 2001, 2 : 287 - 289
  • [33] Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma
    Zhu Ning
    Gong Yi
    Chen Xiao-dong
    Zhang Jing
    Long Feng
    He Jian
    Xia Jing-wen
    Dong Liang
    CHINESE MEDICAL JOURNAL, 2013, 126 (15) : 2943 - 2951
  • [34] Global and local determinants for the kinetics of interleukin-4/interleukin-4 receptor alpha chain interaction - A biosensor study employing recombinant interleukin-4-binding protein
    Shen, BJ
    Hage, T
    Sebald, W
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 240 (01): : 252 - 261
  • [35] A PHASE-I TRIAL OF CONTINUOUS-INFUSION INTERLEUKIN-4 (IL-4) ALONE AND FOLLOWING INTERLEUKIN-2 (IL-2) IN CANCER-PATIENTS
    SOSMAN, JA
    FISHER, SG
    KEFER, C
    FISHER, RI
    ELLIS, TM
    ANNALS OF ONCOLOGY, 1994, 5 (05) : 447 - 452
  • [36] Interleukin-4, interleukin-4 receptor, and interleukin-18 polymorphisms and rheumatoid arthritis: a meta-analysis
    Song, Gwan Gyu
    Bae, Sang-Cheol
    Kim, Jae-Hoon
    Lee, Young Ho
    IMMUNOLOGICAL INVESTIGATIONS, 2013, 42 (06) : 455 - 469
  • [37] Effects of aprotinin on serum interleukin-2 and soluble interleukin-2 receptor during cardiopulmonary bypass
    Luo Jun
    Wang Dongfang
    Lan Hongjun
    Sun Zongquan
    Current Medical Science, 2000, 20 (2) : 143 - 144
  • [38] QUANTITATIVE DIFFERENCES IN INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION BY ANTIGEN-STIMULATED SPLENOCYTES FROM INDIVIDUALLY-HOUSED AND GROUP-HOUSED MICE
    KARP, JD
    COHEN, N
    MOYNIHAN, JA
    LIFE SCIENCES, 1994, 55 (10) : 789 - 795
  • [39] Effects of Aprotinin on Serum Interleukin-2 and Soluble Interleukin-2 Receptor during Cardiopulmonary Bypass
    罗军
    汪东仿
    蓝鸿钧
    孙宗全
    JournalofTongjiMedicalUniversity, 2000, (02) : 143 - 144
  • [40] DOWN-REGULATION OF INTERLEUKIN-2 RECEPTOR EXPRESSION ON NATURAL-KILLER-CELLS LARGE GRANULAR LYMPHOCYTES BY INTERLEUKIN-4
    BOSSE, D
    ADES, E
    PATHOBIOLOGY, 1992, 60 (02) : 72 - 75
12345