INTERACTION OF INTERLEUKIN-2 AND INTERLEUKIN-4 DURING LAK CELL GENERATION

被引：0
|
作者：
INDROVA, M
JANDLOVA, T
BUBENIK, J
机构：
来源：
FOLIA BIOLOGICA | 1992年 / 38卷 / 01期
关键词：
INTERLEUKIN-2; INTERLEUKIN-4; LAK CELLS;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Immunoregulatory lymphokines IL-2 and IL-4 produced by IL-2- and IL-4-cDNA-transformed somatic cells were used for LAK cell generation. The cytolytic effect of LAK cells activated for 3 days with IL-2 and measured by Cr-51 release of three types of target cells, YAC-1 (NK-sensitive), C1498 (NK-resistant) and X63-Ag8.653 (plasmocytoma cell line utilized for insertion of the IL-2 and Il-4 genes), was significantly depressed by adding IL-4 during the activation period.
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页码：1 / 9
页数：9
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