EPIDERMAL GROWTH-FACTOR RECEPTOR INTERNALIZATION AND BIOSYNTHESIS IN THE DIABETIC RAT

被引：7
作者：
DEDIEGO, JG
ROUILLER, DG
GORDEN, P
CARPENTIER, JL
机构：
[1] NIDDKD, DIABET BRANCH, BETHESDA, MD USA
[2] UNIV GENOA, MED CTR, LABS LOUIS JEANTET, I-16126 GENOA, ITALY
来源：
EXPERIMENTAL CELL RESEARCH | 1992年 / 200卷 / 01期
关键词：
D O I：
10.1016/S0014-4827(05)80073-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The number of surface EGF receptors as well as their internalization rate and biosynthesis were analyzed in hepatocytes freshly isolated from control, streptozotocin-diabetic, and insulin-treated diabetic rats. All three parameters were decreased in diabetic animals and values were corrected by insulin treatment. Moreover, the inhibition of synthesis was specific for the EGF receptor since the other biosynthetically labeled proteins were not affected. These data demonstrate that the reduced number of hepatocyte surface EGF receptors results from an inhibition of EGF-receptor synthesis which is not compensated by a reduced internalization rate. © 1992 Academic Press, Inc.
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页码：77 / 82
页数：6
相关论文
共 41 条
[1]   RECENT STUDIES ON INSULIN-BINDING ANTIBODIES [J].
BERSON, SA ;
YALOW, RS .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1959, 82 (02) :338-344
[2]  
BLACKSHEAR PJ, 1987, J BIOL CHEM, V262, P12356
[3]   INHIBITION OF GASTRIC-ACID SECRETION BY EPIDERMAL GROWTH-FACTOR [J].
BOWER, JM ;
CAMBLE, R ;
GREGORY, H ;
GERRING, EL ;
WILLSHIRE, IR .
EXPERIENTIA, 1975, 31 (07) :825-826
[4]   EPIDERMAL GROWTH-FACTOR [J].
CARPENTER, G ;
COHEN, S .
ANNUAL REVIEW OF BIOCHEMISTRY, 1979, 48 :193-216
[5]   THE FATE OF [I-125-LABELED IODOEPIDERMAL GROWTH-FACTOR IN ISOLATED HEPATOCYTES - A QUANTITATIVE ELECTRON-MICROSCOPIC AUTORADIOGRAPHIC STUDY [J].
CARPENTIER, JL ;
GORDEN, P ;
FREYCHET, P ;
CANIVET, B ;
ORCI, L .
ENDOCRINOLOGY, 1981, 109 (03) :768-775
[6]   I-125 INSULIN BINDING TO CULTURED HUMAN LYMPHOCYTES - INITIAL LOCALIZATION AND FATE OF HORMONE DETERMINED BY QUANTITATIVE ELECTRON-MICROSCOPIC AUTORADIOGRAPHY [J].
CARPENTIER, JL ;
GORDEN, P ;
AMHERDT, M ;
VANOBBERGHEN, E ;
KAHN, CR ;
ORCI, L .
JOURNAL OF CLINICAL INVESTIGATION, 1978, 61 (04) :1057-1070
[7]   RECEPTOR-MEDIATED ENDOCYTOSIS OF POLYPEPTIDE HORMONES IS A REGULATED PROCESS - INHIBITION OF [I-125] IODOINSULIN INTERNALIZATION IN HYPOINSULINEMIC DIABETES OF RAT AND MAN [J].
CARPENTIER, JL ;
ROBERT, A ;
GRUNBERGER, G ;
VANOBBERGHEN, E ;
FREYCHET, P ;
ORCI, L ;
GORDEN, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 63 (01) :151-155
[8]   EPIDERMAL GROWTH-FACTOR REGULATES THE EXPRESSION OF ITS OWN RECEPTOR [J].
CLARK, AJL ;
ISHII, S ;
RICHERT, N ;
MERLINO, GT ;
PASTAN, I .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8374-8378
[9]  
Cohen S, 1974, Recent Prog Horm Res, V30, P551
[10]  
COHEN S, 1962, J BIOL CHEM, V237, P1555
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